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Molecular Evolution

Molecular-Evolution Several aspecs of molecular evolution are here considered, basically those that can be investigated by bioinformatics strategies. Specifically, the main interests are on structure and functional analyses of gene families and comparative genomics in plants and animals.

Activity start 1998
Publications - Licciardello C, D'Agostino N, Traini A, Recupero GR, Frusciante L, Chiusano ML. Characterization of the glutathione S-transferase gene family through ESTs and expression analyses within common and pigmented cultivars of Citrus sinensis (L.) Osbeck. BMC Plant Biol. 2014 Feb 3;14(1):39. doi: 10.1186/1471-2229-14-39. PubMed PMID: 24490620; PubMed Central PMCID: PMC3922800.  Q1
- Sangiovanni M, Vigilante A, Chiusano ML. Exploiting a Reference Genome in Terms of Duplications: The Network of Paralogs and Single Copy Genes in Arabidopsis thaliana. Biology 2013;2(4), 1465-1487; doi:10.3390/biology2041465.
- Traini A, Iorizzo M, Mann H, Bradeen JM, Carputo D, Frusciante L, Chiusano ML. Genome Microscale Heterogeneity among Wild Potatoes Revealed by Diversity Arrays Technology Marker Sequences. Int J Genomics. 2013;2013:257218. doi: 10.1155/2013/257218. Epub 2013 May 8. PubMed PMID: 23738318; PubMed Central PMCID: PMC3664788.
- Quirin EA, Mann H, Meyer RS, Traini A, Chiusano ML, Litt A, Bradeen JM. Evolutionary meta-analysis of solanaceous resistance gene and solanum resistance gene analog sequences and a practical framework for cross-species comparisons. Mol Plant Microbe Interact. 2012 May;25(5):603-12. doi:10.1094/MPMI-12-11-0318-R. PubMed PMID: 22352721.
- Natale A, Sims C, Chiusano ML, Amoroso A, D'Aniello E, Fucci L, Krumlauf R, Branno M, Locascio A. Evolution of anterior Hox regulatory elements among chordates. BMC Evol Biol. 2011 Nov 15;11:330. doi: 10.1186/1471-2148-11-330. PubMed PMID: 22085760; PubMed Central PMCID: PMC3227721. Q1
- Chiusano ML, Di Giaimo R, Potenza N, Russo GM, Geraci G, del Gaudio R. A possible flip-flop genetic mechanism for reciprocal gene expression. FEBS Lett. 2005 Sep 12;579(22):4919-22. PubMed PMID: 16139277. Q1
- Potenza N, del Gaudio R, Chiusano ML, Russo GM, Geraci G. Specificity of cellular expression of C. variopedatus polychaete innexin in the developing embryo: evolutionary aspects of innexins' heterogeneous gene structures. J Mol Evol. 2003;57 Suppl 1:S165-73. PubMed PMID: 15008413. Q1
- Facchiano AM, Stiuso P, Chiusano ML, Caraglia M, Giuberti G, Marra M, Abbruzzese A, Colonna G. Homology modelling of the human eukaryotic initiation factor 5A (eIF-5A). Protein Eng. 2001 Nov;14(11):881-90. PubMed PMID: 11742107.
- Chiusano ML, Alvarez-Valin F, Di Giulio M, D'Onofrio G, Ammirato G, Colonna G, Bernardi G. Second codon positions of genes and the secondary structures of proteins. Relationships and implications for the origin of the genetic code. Gene. 2000 Dec 30;261(1):63-9. PubMed PMID: 11164038. Q2
- Chiusano ML, D'Onofrio G, Alvarez-Valin F, Jabbari K, Colonna G, Bernardi G. Correlations of nucleotide substitution rates and base composition of mammalian coding sequences with protein structure. Gene. 1999 Sep 30;238(1):23-31. PubMed PMID: 10570980. Q2
- del Gaudio R, Potenza N, Stefanoni P, Chiusano ML, Geraci G. Organization and nucleotide sequence of the cluster of five histone genes in the polichaete worm Chaetopterus variopedatus: first record of a H1 histone gene in the phylum Annelida. J Mol Evol. 1998 Jan;46(1):64-73. PubMed PMID: 9419226. Q1
Permanent staff Chiusano Maria Luisa (BIO/11), Carputo Domenico (AGR07), Frusciante Luigi (AGR/07)
Temporary or external staff Collaboratori non strutturati o ex non strutturati che hanno partecipato alle attività:
- D'Agostino Nunzio: ex PhD and Post DOC, attualmente ricercatore al CRA, Pontecagnano Salerno
- Licciardello Concetta ex PhD e attualmente ricercatore al CRA, Acireale, Catania
- Sangiovanni Mara: ex borsista e attualmente PhD student presso Università degli Studi di Napoli Federico II
- Traini Alessandra: ex PhD and Post Doc attualmente senior scientist presso Wellcome Trust Genome Campus, Cambridge, Inghilterra
- Vigilante Alessandra: ex PhD e attualmente Post Doc presso UCL Genetics Institute, University College London, Inghilterra
Collaboratori principali responsabili da altri istituti:
- Alvarez-Valin F., Universita' di Montevideo, Uruguay
- Bernardi G., Università Roma 3
- Bradeen JM., University of Minnesota, USA
- Colonna G., Seconda Università di Napoli, Napoli
- Facchiano A., CNR-ISA, Avellino
- Geraci G., Università degli Studi di Napoli Federico II, Napoli
- Gojobori T., National Institute of Advanced Industrial Science and Technology, Tokyo, Japan
- Locascio A., Stazione Zoologica A. Dohrn, Napoli
Collaborations  
SSD  
Projects - Agronanotech I (2004-2006))e II (2008-2011), MIPAF, Italia (responsabile UO)
- Genopom I (2005-2010), GenopomPRO and GenHORT (2007-2013), MIUR, Italia (responsabile UO)
- EUSOL, VI programma quadro, EU (responsabile UO), 2005-2010
- SPOT-ITN, VII programma quadro, EU (responsabile UO), 2012-2015
Recognitions and awards La dott. Chiusano e' invitata come relatore al:
- Convegno the 1st Anton Dohrn Workshop: Neutralism and Selectionism: the end of a debate, 4-6 Maggio 2000, Ischia
- Convegno 5th Anton Dohrn Workshop: Natural Selection and the Neutral Theory, 23-27 Ottobre 2001, Sorrento
- Convegno Molecular Evolution in the Genomics Era, International Union of Biological Sciences, 29 Settembre-1 Ottobre, Roma
Scientific events La Dr. Chiusano ha organizzato sessioni di convegni internazionali per le tematiche presentate:
- Chiusano M.L. (2005). Organized the Section: Mining molecular data in the light of structure, function and evolution - Gainesville - Florida - 2-4 Febbraio.
- Chiusano M.L. e Toraldo G. (2004), organizers of the Bioinformatics Section. Computational Management Science Conference (CMS) and Workshop on Computational Econometrics and Statistics- Neuchatel - Switzerland - 2-5 Aprile. 
Technology and know-how transfers  
Other