Polydnavirus and immunosuppression

Polydnavirus-and-immunosuppression Molecular and functional studies on symbiotic viruses associated with parasitic wasps, which suppress the immune response and disrupt the development of the attacked insect host. The virulence factors encoded by these viruses are good candidates for the development of new bioinsecticides.

Activity start  
Publications - White JA, M Giorgini, MR Strand, F Pennacchio, 2013. Arthropod Endosymbiosis and Evolution. In Arthropod Biolology and Evolution (eds. A Minelli, G Boxshall, G Fusco) Springer, pp. 441-478.
- PENNACCHIO F., MANCINI D. – 2012 – Aphid parasitoid venom and its role in host regulation. In: “Parasitoid Viruses: Symbionts and Pathogens” (eds. N. Beckage and J.-M. Drezen). Elsevier, pp. 247-254
- PENNACCHIO F, GIORDANA B, RAO R. 2012Application of parasitoid virus and venom research in agriculture. In: “Parasitoid Viruses: Symbionts and Pathogens” (eds. N. Beckage and J.-M. Drezen). Elsevier : 269-283.
- Duchi S.,Cavaliere V., Fagnocchi L., Grimaldi M.R., Falabella P.,Graziani F., Gigliotti S., Pennacchio F., Gargiulo G.(2010).The impact on microtubule network of a bracovirus IKB-likeprotein.CELLULAR AND MOLECULAR LIFE SCIENCES (ISSN:1420-9071)pp.1699- 1712 Vol.67, Q1
- Falabella P, Riviello L, Pascale M, Di Lelio I, Tettamanti G, Grimaldi A, Iannone C, Monti M, Pucci P, Tamburro AM, Deeguileor M, Gigliotti S, Pennacchio F(2012). Functional amyloids in insect immune response. IBMB (ISSN:0965-1748)   pp.203- 211 Vol.42, Q1
- A. J.Pruijssers,P. Falabella,J. H. Eum,F. Pennacchio,M. R. Brown,M. R. Strand (2009). Infection by a symbiotic polydnavirus induces wasting and inhibits metamorphosis of the moth Pseudoplusiaincludens. J EXP BIOL (ISSN:0022-0949). 212: 2998- 3006, Q1
- FALABELLA P; VARRICCHIO P; PROVOST B; FERRARESE R; GRIMALDI A; DE EGUILEOR M; FIMIANI G; URSINI M. V; MALVA C; DREZEN J-M; F. PENNACCHIO (2007). Characterization of the IkB-like gene family in polydnaviruses associated with wasps belonging to different Braconid subfamilies. JOURNAL OF GENERAL VIROLOGY (ISSN:0022-1317) 88: 92-104, Q1
- P. Falabella,P. Caccialupi,P. Varricchio,C. Malva,F. Pennacchio, 2006. Protein tyrosine phosphatases of Toxoneuron nigriceps bracovirus as potential disrupter of host prothoracic gland function. ARCH INSECT BIOCHEM PHYSIOL (ISSN:0739-4462) 61:157-69, Q1
- R. Lapointe,R. Wilson,L. Vilaplana,D. R. O'Reilly,P. Falabella,V. Douris,M. Bernier-Cardou,F. Pennacchio,K. Iatrou,C. Malva,J. A. Olszewski, 2005. Expression of a Toxoneuron nigriceps polydnavirus-encoded protein causes apoptosis-like programmed cell death in lepidopteran insect cells. JOURNAL OF GENERAL VIROLOGY (ISSN:0022-1317) 86:963-71, Q1
- B. Provost,P. Varricchio,E. Arana,E. Espagne,P. Falabell, E. Huguet,R. L. Scaleia,L. Cattolico,M. Poirie, C. Malva,JA Olszewski,F Pennacchio,J.M Drezen, 2004. Bracoviruses contain a large multigene family coding for protein tyrosine phosphatases. JOURNAL OF VIROLOGY (ISSN:0022-538X)78:13090-103, Q1
Permanent staff Francesco Pennacchio, PO. Silvia Caccia, RTD, AGR/11
Temporary or external staff Ilaria Di Lelio, Ass. Paola Varricchio, Ass, Magda De Eguilor, UNINI, Morena Casartelli, UNIVR, Silvia Gigliotti, CNR-IGB, Massimo Giorgini, CNR-IPSP, Patrizia Falabella, UNIBAS, Giuseppe Gargiulo, UNIBO
Projects Genetic resources of beneficial organisms for sustainable agriculture. Ministry of Agriculture MIPAF Coordinator sub-project on insects; 2002-2005; value 600K.
Geni di origine parassitaria e loro uso in strategie innovative di controllo degli insetti. MIUR COFIN2008. 200K (intero progetto)
Recognitions and awards  
Scientific events  
Technology and know-how transfers