Insect pathology and biopesticides

Insect-pathology-and-biopesticides Studies on insect pathogens and on natural molecules with insecticidal activity. Special emphasis is devoted to toxins produced by Bacillus thuringiensis, which is one of the most used and effective antagonists of insects.

Activity start  
Publications - M. Hamshou, E.J.M. Van Damme, S. Caccia, K. Cappelle, G. Vandenborre, B. Ghesquière, K. Gevaert, G. Smagghe (2013). High entomotoxicity and mechanism of the fungal GalNAc/Gal-specific Rhizoctoniasolanilectin in pest insects. Journal of InsectPhysiology 59, 295-305. IF 2012: 2,379. Q1.
- Digilio MC, Sasso R, Di Leo MG, Iodice I, Monti MM, Santeramo R, Arpaia S, Guerrieri E, 2012. Interactions between Bt-expressing tomato and non-target insects: the aphid Macrosiphum euphorbiae and its natural enemies. J. Plant Interactions 7 (1): 71-77. Q3
- M. Chakroun, Y. Bel, S. Caccia, L. Abdelkefi-Mesrati, B. Escriche, J. Ferré (2012). Susceptibility of Spodopterafrugiperda and S. exigua to Bacillus thuringiensisVip3Aa insecticidal protein. Journal of Invertebrate Pathology 110, 334-339. Q1.
- S. Caccia, W.J. Moar, J. Chandrashekhar, C. Oppert,K.J. Anilkumar, J.L. Jurat-Fuentes, J. Ferré (2012). Association of Cry1Ac toxin resistance in Helicoverpazea(Boddie) with increased alkaline phosphatase levels in the midgut lumen. Applied and Environmental Microbiology 78, 5690-5698. Q1.
- S. Caccia, E.J.M. Van Damme, W.H. De Vos, G. Smagghe, 2012. Mechanism of entomotoxicity of the plant lectin from Hippeastrum hybrid (in Spodoptera littoralis larvae.J Insect Physiol 58: 1177-83. Q1.
- Fiandra L., Terracciano I., Fanti P., Garonna A., Ferracane L., Fogliano V., Casartelli M., Giordana B., Rao R., Pennacchio F.,2010. A viral chitinase enhances oral activity of TMOF. IBMB (0965-1748) 40: 533-40 Q1
- A.K.Jakubowska, S. Caccia, K.H. Gordon, J. Ferré, S. Herrero (2010). Downregulation of a chitin deacetylase-like protein in response to baculovirus infection and its application for improving baculovirus infectivity. Journal of Virology 84, 2547-2555. Q1.
- S. Caccia, C.S. Hernández-Rodríguez, R.J. Mahon, S. Downes, W. James, N. Bautsoens, J. Van Rie and J. Ferré (2010). Binding site alteration is responsible for field-isolated resistance to Bacillus thuringiensis Cry2A insecticidal proteins in two Helicoverpa species. PLoS ONE 5: e9975. doi:10.1371/journal.pone.0009975. Q1.P. Hernández-Martínez, G. Navarro-Cerrillo, S. Caccia, R.A. de Maagd, W.J.Moar, J. Ferré, B. Escriche, S. Herrero (2010). Constitutive activation of the midgut response to Bacillus thuringiensis in Bt-resistant Spodoptera exigua. PLoS ONE 5(9):e12795. doi: 10.1371/journal.pone.0012795. IF 2012: 3,730. Q1.
- A. Rodrigo-Simón, S. Caccia, J. Ferré (2008). Bacillus thuringiensisCry1Ac toxin binding and pore forming activity in brush border membrane vesicles prepared from anterior and posterior midgut regions of lepidopteran larvae. Applied and Environmental Microbiology 74, 1710-1716. IF 2012: 3,678. Q1.
Permanent staff Francesco Pennacchio, PO. Antonio Pietro Garonna, PA. Maria Cristina Digilio, PA. Silvia Caccia, RTD, AGR/11
Temporary or external staff  
Projects - Futuro in Ricerca 2013, MIUR“Meccanismo d’azione e resistenza di Bacillus thuringiensis: una nuova prospettiva”, Principal Investigator , 351.147,00 euro.
- Insect functional genomics for the development of innovative plant protection strategies.  MIUR FIRB, National coordinator; 2002-2006, value 1050K
- European PhD course in Insect Biotechnology. MIUR. Coordinator; 2002-2005, value 220K
- European PhD course in Insect Science and Biotechnology. MIUR Coordinator; 2005-2008, value 200K.
Recognitions and awards  
Scientific events  
Technology and know-how transfers