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Foods/Ingredients and Disease Prevention

Foods ingredients and disease prevention Intervention studies in humans and animals are performed in order to clarify mechanisms underlying the ability of foods/ingredients to protect the body from chronic diseases driven by oxidative stress and inflammation. Biological samples are collected and specific analysis based on multiplexed assays, LC/MS/MS and pectrophotometric analysis are performed.

Activity start 2003
Publications - Vitaglione P, Mennella I, Ferracane R, Rivellese AA, Giacco R, Ercolini D, Gibbons SM, La Storia A, Gilbert JA, Jonnalagadda S, Thielecke F, Gallo MA, Scalfi L, Fogliano V. Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber. Am J Clin Nutr. 2015;101(2):251-611.  (Q1 – Nutrition and dietetics).
- Grosso G, Mistretta A, Frigiola A, Gruttadauria S, Biondi A, Basile F, Vitaglione P, D'Orazio N, Galvano F. Mediterranean diet and cardiovascular risk factors: a systematic review. Crit Rev Food Sci Nutr. 2014;54(5):593-610. doi: 10.1080/10408398.2011.596955. (Q1 – Nutrition and dietetics; Food science and technology)
- D'Argenio G, Mazzone G, Ribecco MT, Lembo V, Vitaglione P, Guarino M, Morisco F, Napolitano M, Fogliano V, Caporaso N. Garlic extract attenuating rat liver fibrosis by inhibiting TGF-β1. Clin Nutr. 2013;32(2):252-8. doi: 10.1016/j.clnu.2012.07.001. (Q2 – Nutrition and dietetics)
- Visioli F, De La Lastra CA, Andres-Lacueva C, Aviram M, Calhau C, Cassano A, D'Archivio M, Faria A, Favé G, Fogliano V, Llorach R, Vitaglione P, Zoratti M, Edeas M. Polyphenols and human health: a prospectus. Crit Rev Food Sci Nutr. 2011;51(6):524-46. doi: 10.1080/10408391003698677. (Q1 – Nutrition and dietetics)
- Fini L, Piazzi G, Daoud Y, Selgrad M, Maegawa S, Garcia M, Fogliano V, Romano M, Graziani G,Vitaglione P, Carmack SW, Gasbarrini A, Genta RM, Issa JP, Boland CR, Ricciardiello L. Chemoprevention of intestinal polyps in ApcMin/+ mice fed with western or balanced diets by drinking annurca apple polyphenol extract. Cancer Prev Res (Phila). 2011;4(6):907-15. doi: 10.1158/1940-6207.CAPR-10-0359. (Q1 – Oncology)
- Vitaglione P, Morisco F, Mazzone G, Amoruso DC, Ribecco MT, Romano A, Fogliano V, Caporaso N, D'Argenio G. Coffee reduces liver damage in a rat model of steatohepatitis: the underlying mechanisms and the role of polyphenols and melanoidins. Hepatology. 2010;52(5):1652-61. doi: 10.1002/hep.23902. (Q1 – Gastroenterology and Hepatology)
- D'Argenio G, Amoruso DC, Mazzone G, Vitaglione P, Romano A, Ribecco MT, D'Armiento MR, Mezza E, Morisco F, Fogliano V, Caporaso N. Garlic extract prevents CCl(4)-induced liver fibrosis in rats: The role of tissue transglutaminase. Dig Liver Dis. 2010;42(8):571-7. doi: 10.1016/j.dld.2009.11.002. (Q2 – Gastroenterology and Hepatology)
- Pannellini T, Iezzi M, Liberatore M, Sabatini F, Iacobelli S, Rossi C, Alberti S, Di Ilio C, Vitaglione P, Fogliano V, Piantelli M. A dietary tomato supplement prevents prostate cancer in TRAMP mice. Cancer Prev Res (Phila). 2010;3(10):1284-91. doi: 10.1158/1940-6207.CAPR-09-0237. (Q1 – Oncology)
- Vitaglione P, Fogliano V, Stingo S, Scalfi L, Caporaso N, Morisco F. Development of a tomato-based food for special medical purposes as therapy adjuvant for patients with HCV infection. Eur J Clin Nutr. 2007;61(7):906-15. (Q2 – Nutrition and Dietetics)
- Vitaglione P, Morisco F, Caporaso N, Fogliano V. Dietary antioxidant compounds and liver health. Crit Rev Food Sci Nutr. 2004;44(7-8):575-86. (Q1 – Nutrition and Dietetics)
- Morisco F, Vitaglione P, Carbone A, Stingo S, Scarpati S, Ascione A, Marmo R, Fogliano V, Caporaso N. Tomato-based functional food as interferon adjuvant in HCV eradication therapy. J Clin Gastroenterol. 2004;38(6 Suppl):S118-20. (Q2 – Gastroenterology and Hepatology)
Permanent staff Paola Vitaglione (BIO/09), Vincenzo Fogliano (CHIM/10)
Temporary or external staff Nicola Caporaso, PO, UNINA, Dip. Medicina Clinica e Chirurgia, Filomena Morisco, PA, UNINA, Dip. Medicina Clinica e Chirurgia
Collaborations  
SSD  
Projects - Validation of new functional foods in humans (Campania Municipality) – 2008, Euro 200.000 - (PV: Project team and scientific responsible of activity)
- D.Lg 297/99 Art. 5 Project "New types of dietary fiber-enriched fresh and dry pasta" in cooperation with Pastificio Leonessa (MIUR), 2005, Euro 351.000 - (PV: Project team and scientific responsible of activity)
- Nutrition Education "Knowledge that nutrishes" – Educational cartoon "La famiglia Rigatoni" (Campania Municipality), 2009, Euro 40.000 - (PV: Project team and text building)
Recognitions and awards Lectures to international conference (P Vitaglione):
- Coffee components and non-alcoholic fatty liver disease - 6th Probiotics, prebiotics and New Foods, Roma, 11-13 September 2011
- Bioactive compounds and liver health: which outcomes and which biomarkers? - COST ACTION 927 Conference “Bioactive compounds from food processing: biotransformation and biological significance”. Granada, 8-10 May 2008
Scientific events  
Technology and know-how transfers  
Other