Bioavailability of Bioactive Compounds

Bioavailability of bioactive compounds Bioavailability of bioactive compounds plays a central role in the possibility of food components to act in vivo upon short- and long-term consumption. Randomized controlled trials in humans are performed. Blood, urine and fecal samples are collected and analysed by LC/MS/MS, HPLC/DAD and Orbitrap.

Activity start 2004
Publications - Vitaglione P, Barone Lumaga R, Ferracane R, Sellitto S, Morelló JR, Reguant Miranda J, Shimoni E, Fogliano V. Human bioavailability of flavanols and phenolic acids from cocoa-nut creams enriched with free or microencapsulated cocoa polyphenols. Br J Nutr. 2013;109(10):1832-43. doi: 10.1017/S0007114512003881. (Q1 – Nutrition and dietetics)
- Vitaglione P, Barone Lumaga R, Ferracane R, Radetsky I, Mennella I, Schettino R, Koder S, Shimoni E, Fogliano V. Curcumin bioavailability from enriched bread: the effect of microencapsulated ingredients. J Agric Food Chem. 2012;60(13):3357-66. doi: 10.1021/jf204517k. (Q1 – Food science and technology – Chemistry, applied -  Agriculture, multidisciplinary)
- Azzini E, Vitaglione P, Intorre F, Napolitano A, Durazzo A, Foddai MS, Fumagalli A, Catasta G, Rossi L, Venneria E, Raguzzini A, Palomba L, Fogliano V, Maiani G. Bioavailability of strawberry antioxidants in human subjects. Br J Nutr. 2010;104(8):1165-73. doi: 10.1017/S000711451000187X. (Q1 – Nutrition and dietetics)
- Vitaglione P, Ottanelli B, Milani S, Morisco F, Caporaso N, Fogliano V. Dietary trans-resveratrol bioavailability and effect on CCl4-induced liver lipid peroxidation. J Gastroenterol Hepatol. 2009;24(4):618-22. doi: 10.1111/j.1440-1746.2008.05598.x. (Q2 – Gastroenterology & Hepatology)
- Galvano F, Vitaglione P, Li Volti G, Di Giacomo C, Gazzolo D, Vanella L, La Fauci L, Fogliano V. Protocatechuic acid: the missing human cyanidins' metabolite. Mol Nutr Food Res. 2008;52(3):386-7; author reply 388. doi: 10.1002/mnfr.200890011. (Q1 – Food Science and technology)
- Vitaglione P, Donnarumma G, Napolitano A, Galvano F, Gallo A, Scalfi L, Fogliano V. Protocatechuic acid is the major human metabolite of cyanidin-glucosides. J Nutr. 2007;137(9):2043-8. (Q1 – Nutrition and dietetics)
- Vitaglione P, Sforza S, Galaverna G, Ghidini C, Caporaso N, Vescovi PP, Fogliano V, Marchelli R. Bioavailability of trans-resveratrol from red wine in humans. Mol Nutr Food Res. 2005;49(5):495-504. (Q1 – Food Science and technology)
Permanent staff Paola Vitaglione (BIO/09), Vincenzo Fogliano (CHIM/10)
Temporary or external staff  
Projects - Bioavailability of ferulic acid from whole grain – in cooperation with General Mills (USA), 2011, Euro 120.000 (PV: Project coordinator and Principal Investigator)
- NANOFOODS - Development of foods containing nanoencapsulated ingredient (EC), 2008, Euro 726.000 - (PV: Project team and scientific responsible of activity)
- BIOCURCUMIN - Platform for enhanced bioavailability and smart delivery of biologically active ingredients "Italy-Israel R&D Cooperation Program" (Italian Foreign Ministry), 2008, Euro 99.335 - (PV: Project team and scientific responsible of activity)
Recognitions and awards Lectures to international conference (P Vitaglione):
- Health benefits of wholegrain: an intervention study to clarify underlying mechanisms and the role of polyphenols bound to dietary fiber -20th International Congress of Nutrition, Granada, 15-20 September 2013
- Whole grain and colon cancer: the antioxidant and inflammatory working hypotheses - International symposium on  “Natural products in cancer prevention and therapy – Napoli, 25-28 June 2013
Scientific events  
Technology and know-how transfers